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Common genetic variants increase risk of aortic dissection
Dianna Milewicz, M.D., Ph.D. director of the John Ritter Research Program, and her team of researchers at UTHealth, along with researchers at Baylor College of Medicine, published the discovery of common genetic variants which predispose individuals to thoracic aortic aneurysms and dissection (TAAD) in the absence of a family history of the disease (called sporadic TAAD) or a genetic syndrome which causes TAAD. The variants are located in the same region on chromosome 15 as the FBN1 gene; changes (mutations) in FBN1 cause Marfan syndrome. The researchers hope an increased understanding of how mutations and variants in FBN1 lead to thoracic aortic disease will ultimately result in effective treatments for individuals with sporadic TAAD.
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